Acute neurotoxicity of acetaminophen in chicks

Acetaminophen is a non-steroidal drug used as an anti-inflammatory, analgesic and antipyretic in humans animals. In chicks, neurotoxicity associated with acetaminophen has not been fully elucidated. The aim of this study was to identify the neurobehavioral, biochemical histopathological effects 7 day-old broiler chicks. acute LD50 estimated by up- and- down method, then influence on open field activity tonic immobility test recorded. behavioral signs toxicity scores were liver enzymes, aspartate aminotransferase (AST) alanine (ALT) activities estimated. Histopathology brain performed. value chicks 1077 mg/kg, intramuscularly. reduced general locomotive measured open- arena, result significant rise latency moving from central square, reduction numbers lines crossed well vocalization score compared control. Intramuscular injections at doses 500 1000 mg/kg induced toxicosis, such head dropping, closed eyelids, immobility, loss vocalization, recumbency, followed death. Histopathological examination showed presence congestion blood vessels, vasogenic edema necrosis Purkinje cells. Degenerative changes enzyme function dysfunction. Our results show behavioral, data demonstrating that high produced